In the absence of safe and efficacious vaccines, broad-spectrum antiviral preventative and therapeutic strategies would likely represent a front-line defense against infection.Ĭurrent FDA-approved antiviral prophylactic and therapeutic compounds in clinical use against common respiratory-transmitted viruses are predominantly direct-acting antivirals 8, 9. Additionally, emerging respiratory viruses with unknown correlates of protection can require significant lead times before protective vaccines can be developed and distributed 7. While vaccination is generally considered the best strategy to prevent such infections, many known viral strains still lack effective vaccination strategies 5, 6. Further, the aerosol transmission of respiratory infections has facilitated global pandemics with influenza A viruses (IAVs) and coronaviruses and the threat of future pandemics from a variant of these (or currently unknown) viruses remains a source of concern 3, 4. Respiratory viral infections present a major burden to public health and result in significant morbidity and mortality in the global population annually 1, 2. Thus, B3GAT1 may represent a host-directed broad-spectrum antiviral target with utility against clinically relevant respiratory viruses. To understand the potential utility of B3GAT1 induction as an antiviral strategy in vivo, we specifically express B3GAT1 in the murine respiratory epithelium and find that overexpression is not only well-tolerated, but also protects female mice from a lethal viral challenge with multiple influenza viruses, including a pandemic-like H1N1 IAV. Due to this mechanism of action, B3GAT1 expression broadly restricts infection with viruses that require sialic acid for entry, including Victoria and Yamagata lineage IBVs, H1N1/H3N2 influenza A viruses (IAVs), and the unrelated enterovirus D68. Subsequent studies reveal that B3GAT1 activity prevents cell surface sialic acid expression. A top hit from our screen, beta-1,3-glucuronyltransferase 1 (B3GAT1), effectively blocks IBV infection. To discover host antiviral restriction factors that may act as suitable targets for the development of host-directed antiviral therapies, we here conduct a whole-genome CRISPR activation screen with influenza B virus (IBV). Communicable respiratory viral infections pose both epidemic and pandemic threats and broad-spectrum antiviral strategies could improve preparedness for these events.
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The company’s Board, though it is split evenly between men and women, is 80 percent white.What I Received in My thredUP Men’s Rescue Box #2Įarlier this month, I received my second thredUP men’s rescue box. Women made up 66 percent of the workforce and 60 percent of senior leadership. Minority employees made up 72 percent of the workforce and 26 percent of senior leadership. Though Black and Latinx employees made up 58 percent of ThredUp’s total workforce, they accounted for just 3 percent of senior leadership. ThredUp’s Impact Report also offered insight into diversity within the company and leadership. Last year, ThredUp opened a new flagship distribution center in Dallas that it claims has some of its most advanced technology, including a multi-level garment storage system that provides 25 percent higher storage density while consuming 40 percent less energy than prior iterations. based shipping emissions decreased 35 percent last year, ThredUp said.Īnother place the company is looking to decrease its impact is at its distribution centers. One way ThredUp has sought to reduce shipping emissions has been through package consolidation-shipping orders from multiple distribution centers together instead of individually. Of that final number, 61 percent are sold to domestic thrift stores, 20 percent are sold to domestic graders or sorters and 19 percent are sold to international brokers. Of the items ThredUp receives, 61 percent are listed on its core marketplace, 5 percent are sold in discounted “Rescues” bundles and 34 percent are sold to aftermarket channels. This segment accounted for 11 percent of ThredUp’s downstream transportation emissions, the company said. Overall, ThredUp’s 2022 emissions grew 7 percent, however, largely due to increases in Scope 3 emissions as the company included emissions associated with aftermarket shipping for the first time. According to this latest assessment, buying and wearing secondhand clothing reduces carbon emissions by an average of 25 percent, energy usage roughly 22 percent and water usage about 31 percent. Three years later, with more accurate measurements available, it conducted a second LCA to quantify the estimated carbon emissions reduction of resale. ThredUp conducted its first Life Cycle Assessment (LCA) in 2019 with Green Story Inc. According to ThredUp, its RaaS program has saved 8.4 million pounds of CO2e, 23 billion gallons of water and 16 million kWh of energy to date.Ĭanada Goose Launches Canada Re-commerce, Details PFAS-free Future Despite a 2.1 percent decline in RaaS revenue in the fourth quarter last year, ThredUp predicted in March that the business would see full-year revenue up 7.5 percent to 11 percent to $310 million to $320 million in 2023.īy the end of last year, ThredUp recorded notable lifetime achievements, such as listing a total of 7.8 million items through its RaaS program and fielding 480,000 Clean Out Kits-boxes of used goods sent to ThredUp for resale-to date. Since January, the company has added American Eagle and its largest retail partner yet, H&M. Over the course of 2022, ThredUp grew its number of RaaS clients 50 percent to 42 brands, including last year’s newcomers Tommy Hilfiger, Hot Topic and its first plus-size brand Torrid. ThredUp’s resale-as-a-service (RaaS) business saw a substantial increase in clients last year, according to the company’s second annual Impact Report. Available on Amazon - $ - Forget about fuel economy, acceleration times or reliability. We recommend you pay for professional installation if fitting a wired parking camera to your vehicle. There is the option to fit a reversing camera to the Pioneer, which will show its video feed on the unit's display when you select reverse. Audio power output is 200W across four speaker channels. The Pioneer has a 6.94-inch touchscreen display with a resolution of 800 x 480, plus Wi-Fi, Bluetooth HD radio and a 13-band graphic equalizer, There is also an SD card slot for loading in media not held on your smartphone, and USB Quick Charge is supported for Android devices. There's also Alexa (via your phone's web connection), Pandora, and support for Siri Eyes Free. You can opt to plug in your phone, if you so wish. It features wireless Apple CarPlay and Android Auto, meaning there is no need to plug in with a USB cable, so your phone can stay in your pocket, in the glovebox, or rest on a wireless charger if your vehicle has one. The AVH-W4500NEX is a flagship double-DIN head unit from Pioneer. The AVH-W4500NEX has wireless CarPlay and Android Auto However some single-DIN systems exist where the display slides out of where a CD slot would be and flips upwards.Ī quick warning: Car head unit makers are often terrible at naming their products, so you'll have to forgive us for repeating their meaningless, alphabet soup-inspired names. But it means older vehicles with poor stereos can be upgraded to the latest Silicon Valley has to offer.Īpple CarPlay systems - which in most cases come with Android Auto too - tend to be double-DIN sized. This design may not win many design awards. Obviously, such simplicity harks back to a time when car interiors and dashboards were sparse and more slab-sided than they are today. This is the size of a single DIN unit, while a double DIN is the same width, but four inches high instead of two. DIN refers to a stereo - also known as a head unit - measuring two inches by eight inches. Here is everything you need to know about adding CarPlay and Android Auto (in some cases wirelessly) to your car, and some of the best options available to buy right now.ĭIN stands for the German phrase, " Deutsches Institut für Normung," and refers to a standard size of stereo the country's car makers began installing in the 1980s. But hey also bring CarPlay and Android Auto into the mix - and in some cases, wirelessly too. The head units featured in this article include all of the regular in-car entertainment features, like Bluetooth and DAB radio. We have also included a new option from Porsche, which now sells head units designs to fit (and match the look of) its older vehicles, bringing CarPlay and 2020 connectivity to cars that are decades old. But now, with a wireless connection to the car (or the third-party head units listed below) you can leave your phone in your pocket or the glove box, and use CarPlay or Android Auto just as before, freeing up the car's USB socket for powering something else.īut while CarPlay and Android Auto are mostly advertised as options on new cars, there are multiple ways to bring them to your older vehicle, thanks to after-market stereos. Until recently, CarPlay and Android Auto would only work if you plugged your phone into the car with a USB cable. A relatively new bonus for both systems is wireless connectivity. PLAYER_MOVEMENT_DURATION_THRESHOLD_IN_MSįor example, to configure a flat, creative server instead of the default use:.The following environment variables will set the equivalent property in server.properties, where each is described here. PACKAGE_BACKUP_KEEP ( 2) : how many package backups to keep.GID (default derived from /data owner) : can be set to a specific group ID to run the.UID (default derived from /data owner) : can be set to a specific user ID to run the.If it is a preview version, also set PREVIEW to "true" otherwise any specific server version can be provided.Useful when the mobile app is gradually being upgraded across devices PREVIOUS : uses the previously maintained major version.PREVIEW : determines the latest preview version and will auto-upgrade.LATEST : determines the latest (non-preview) version and can be used to auto-upgrade on container start.VERSION ( LATEST) : can be set to a specific server version or the following special values can be used:.EULA (no default) : must be set to TRUE toĪccept the Minecraft End User License Agreement.Itzg/minecraft-server Environment Variables Container Specific Looking for a Java Edition Serverįor Minecraft Java Edition you'll need to use this image instead: The latest preview version can be requested by setting VERSION to "PREVIEW". At every startup, the container checks for the latest version and upgrades, if needed. With the VERSION variable set to "LATEST", which is the default, then the Bedrock server can be upgraded by restarting the container. Upgrading to the latest Bedrock server version NOTE: if you plan on running a server for a longer amount of time it is highly recommended using a management layer such as Docker Compose or Kubernetes to allow for incremental reconfiguration and image upgrades. Docker run -d -it -e EULA=TRUE -p 19132:19132/udp -v mc-bedrock-data:/data itzg/minecraft-bedrock-server For an illustrated counterpart of this list that shows a sample of each font, see A Guide to Cloud Fonts in Microsoft Office 365, created by Julie Terberg, presentation designer and owner of Terberg Design. This is the font used on Red Bull Bragantinos special edition kit to commemorate its winning the 2019 Campeonato Brasileiro Série B and its promotion to Campeonato Brasileiro Série A for the 2020/2021 season. The auction will remain open for 24 hours, with NFTs awarded to the highest bidder. On November 18, at 09:00 (UTC), 45 of the highest value CR7 NFTs (5 SSR and 40 SR) will be held for auction on the Binance NFT marketplace. The inaugural Cristiano Ronaldo NFT collection will drop on November 18 (09:00 UTC) and feature seven animated statues with four rarity levels: Super Super Rare (SSR), Super Rare (SR), Rare (R), and Normal (N).Įach NFT statue depicts Ronaldo in an iconic moment from his life, from career-defining bicycle kicks to his childhood in Portugal. The greatest footballer of his generation, Cristiano Ronaldo, is ready to release his debut NFT collection with Binance. We’re excited to partner with one of the greatest footballers of all time, Cristiano Ronaldo, on an exclusive series of NFT collections. Ronaldo shares his thoughts on NFTs and football in an interview with Binance. Each box contains one of two mystery-box exclusive Ronaldo NFTs in a Stone color. There's also a CR7 Mystery Box giveaway reserved for the first 1.5 million new Binance users. The collection will feature seven animated statues with four rarity levels: Super Super Rare (SSR), Super Rare (SR), Rare (R), and Normal (N).Įach rarity level comes with its own set of exclusive perks, including a personal message from Ronaldo, and signed football shirts. The inaugural Cristiano Ronaldo NFT collection will drop on November 18 (09:00 UTC). When it comes to choosing a capture card, there are several crucial factors that must be taken into account. What to Look for in the Best Capture Card? We haven’t restricted our selection to PC-only cards either standalone and tiny form factor options are also available and highly recommended. With the devices in our roundup, you are able to output in a minimum of 1080p60 as well as 4K without making any sacrifices. In an emergency, broadcasting directly from a console is acceptable, but if you are serious about streaming or making content, you’ll be constrained without a capture card. When recording video on a game console, combining a capture card and a PC or gaming laptop will provide you access to more functionality and broadcasting choices. A dedicated capture card might reduce stress because, depending on your setup, recording using GPU software or a program like OBS can result in blurry footage and a number of other problems. The greatest capture cards will help you out here because they will provide you with an upgrade over what the consoles normally have to offer.Įven if a top-notch capture card may not be absolutely necessary for PC gamers, it will significantly lessen the load on the system’s hardware. The PlayStation 5, Xbox Series X, and the Nintendo Switch can all immediately stream and record gameplay, however, the options that consoles can provide can occasionally be somewhat limited. There are some that even enable you to broadcast while simultaneously showing a picture-in-picture live of yourself by combining your gaming footage and a live feed from a camera. While some capture cards work best with consoles, some are better suited for PC gaming. 2.) AVerMedia GC513 Live Gamer Portable 2 PlusĪ high-quality capture card will assist you acquire fantastic recordings without hindering your play, whether you want to create a professional broadcasting channel or simply enjoy sharing your gaming footage with friends.The Best Capture Cards Available in 2023.What to Look for in the Best Capture Card?. 1.4.1.002: Nerfed the damages of the offensive and defensive guardians from 400% of the player's summon damage to 150%.Offensive and defensive guardians now scale in damage after The Devourer of Gods and/or Jungle Dragon, Yharon have been defeated.Offensive guardian can now activate if the player wears Omega Blue armor.1.4.2.101: Changed flavor text from "Profanation" to "Purity".1.4.2.103: Offensive guardian's buff description now says that it will "fight for you" instead of "protect you".1.4.2.108: Now always gives +1 max minions even while the player is Burnt Out.Fixed minions not benefitting from increased all-class damage.Removed Healer Guardian and Offensive Guardian buffs.Adjusted the buff tooltip of The Profaned Soul buff and allowed it to dynamically affect the status of all three guardians spawned.Renamed buff from "Defensive Guardian" to "The Profaned Soul".Now requires 1 Core of Calamity and 10 Divine Geodes instead of 1 Core of Sunlight and 5 Divine Geodes.Now requires 10 minion slots or higher for the defensive guardian to spawn instead of 8. adjective 1 having intellectual depth and insight difficult to fathom or understand 2 extending far below the surface coming from, reaching to, or.Added an exclamation point at the end of The Profaned Soul's buff tooltip while only the healer is active.Fixed it not checking the player's minion slots properly.1.4.4.002: Slightly adjusted the challenge to allow for damage up to 5% of Providence's max health instead of 1%.This does not affect the minion slot provided by the Offensive Guardian, and the Defensive and Offensive Guardians will continue to attack enemies.Īdditionally, equipping the Profaned Soul Artifact causes all minions to inflict the Holy Flames debuff for 5 seconds. If the player gets hit, they are afflicted with the Profaned Soul Artifact Burnout cooldown for 5 seconds, which negates most of the guardians' stat boosts and healing effects for its duration. The Offensive Guardian deals 52 damage, increased by the player's summon damage stat. The Offensive Guardian also rapidly dashes at enemies and grants the player one extra minion slot.The Defensive Guardian deals 52 damage, increased by the player's summon damage stat. The Defensive Guardian rapidly dashes at enemies, and increases player movement speed and damage reduction by 10% and 5% respectively.The Healer Guardian heals the player for 15 health every 5 seconds.It summons all three miniature Profaned Guardians to assist the player. Ext 359 ) 1 EM ADAMS MS Assoc Prof Ind Ed 4 CLB ADDISON BArch Asst Prof Tech Ed 1 HA HOLMES BS Asst Prof Ind Arts 1 SY HWANG PhD Assoc Prof Civil Eng Tech 1. The Profaned Soul Artifact is a craftable post- Moon Lord accessory. Many Chinese iOS device owners also jailbreak their phones to install third-party Chinese character input systems because they are easier to use than Apple's. Users install these programs for purposes including personalization and customization of the interface using tweaks developed by developers and designers, adding desired features such as access to the root file system and fixing annoyances, and making development work on the device easier by providing access to the file system and command-line tools. Since software programs available through APT and or Installer.app (legacy) are not required to adhere to App Store guidelines, many of them are not typical self-contained apps but instead are extensions and customization options for iOS and its features and other apps (commonly called tweaks). Jailbreaking permits the downloading of programs not approved by Apple, such as user interface customization and tweaks. In one case, Apple mistakenly banned an app by a Pulitzer-Winning cartoonist because it violated its developer license agreement, which specifically bans apps that "contain content that ridicules public figures." To access banned apps, users rely on jailbreaking to circumvent Apple's censorship of content and features. However, the reasons for Apple to ban apps are not limited to safety and security and may be regarded as arbitrary and capricious. Apple checks apps for compliance with its iOS Developer Program License Agreement before accepting them for distribution in the App Store. Since it includes modifying the operating system (enforced by a "locked bootloader"), installing non-officially approved (not available on the App Store) applications via sideloading, and granting the user elevated administration-level privileges (rooting), the concepts of iOS jailbreaking are therefore technically different from Android device rooting.Įxpanding the feature set that Apple and its App Store have restricted is one of the motivations for jailbreaking. While sometimes compared to rooting an Android device, jailbreaking bypasses several types of Apple prohibitions for the end-user. Apple views jailbreaking as a violation of the end-user license agreement and strongly cautions device owners not to try to achieve root access through the exploitation of vulnerabilities. Different devices and versions are exploited with a variety of tools. A jailbroken device permits root access within the operating system and provides the right to install software unavailable through the App Store. Typically it is done through a series of kernel patches. On Apple devices running iOS and iOS-based operating systems, jailbreaking is the use of a privilege escalation exploit to remove software restrictions imposed by the manufacturer. Not to be confused with bootloader unlocking or SIM unlocking. |
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